The MARCH family of RING-finger E3 ubiquitin ligases comprise 11 members that have been reported to play a variety of roles in the downregulation of cell-surface proteins involved in adaptive immunity. The RING-CH domain of MARCH proteins is thought to ubiquitinate the cytoplasmic tails (CTs) of target proteins. leading to protein degradation through either lysosomal or proteasomal pa... https://megavitamines.shop/product-category/betaine-hcl-pepsin-gentian-bitters/