Alpha-dystroglycan requires a rare O-mannose glycan modification to form its binding epitope for extracellular matrix proteins such as laminin. This functional glycan is disrupted in a cohort of muscular dystrophies. the secondary dystroglycanopathies. and is abnormal in some metastatic cancers. https://smokeysmountainfurnitureoutlets.shop/product-category/bed-pillow/