The present study aimed to investigate the antitumor effect of simultaneous inhibition of dihydrofolate reductase (DHFR) enzyme. We designed some novel pyrazolo[3. 4-d]pyrimidines bearing different amino acid conjugates as efficient antifolate agents attributable to their structural similarity with methotrexate (MTX) and MTX-related antifolates. All compounds were tested to screen the... https://www.diegojavierfares.com/flash-find-Bushranger-Awning-2-5m-W-x-2-0m-L-2-Year-No-Fuss-Warranty-AW2000-best-save/